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The study’s primary endpoint was combined remission, defined as clinical assessment at week 24 of closure of all treated external openings draining at baseline despite gentle finger compression, and absence of collections >2cm confirmed by MRI. In the ITT population (n=212), Cx601 achieved statistically significant superiority (p=0.024) on the primary endpoint with 50% combined remission at week 24 compared to 34% in the placebo arm. Efficacy results were robust and consistent across all statistical populations. Treatment emergent adverse events (non-serious and serious) and discontinuations due to adverse events were comparable between Cx601 and placebo arms. The 24-weeks results have been published by The Lancet, one of the most highly regarded and well known medical journals in the world. The Phase III study has completed a follow-up analysis at 52 weeks confirming its sustained efficacy and safety profile. Top line follow-up data showed that in the ITT population Cx601 achieved statistical superiority (p=0.012) with 54% combined remission at week 52 compared to 37% in the placebo arm. The 52-week data also showed a higher rate of sustained closure in those patients treated with Cx601 and in combined remission at week 24 (75.0%) compared to patients in the placebo group (55.9%). Based on the positive 24-weeks Phase III study results, TiGenix has submitted a Marketing Authorization Application to the EMA in early 2016. TiGenix is preparing to develop Cx601 in the U.S. after having reached an agreement with the FDA through a special protocol assessment procedure (SPA) in 2015.
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Pakistani authorities hushed up the crime, but the facts ultimately emerged. Village elders had ordered the girls families to kill them to preserve the honor of the tribe. The local authorities also ordered the extermination of the entire family of a boy who may have been in the room with the girls for a few minutes. check my blogHow can we pretend how can the left insist that a civilization that condones such brutality has the same moral authority as our own? The truest test of a civilization, the basic qualification, is how women are treated. On that day 2,000 years ago, when Jesus stopped a village honor killing, our Judeo-Christian world changed profoundly. No, women didnt attain fully equal rights until the latter half of the 20th century. Yet, there was always a difference. In the West, queens could rule, but there never was a female caliph or sultan. In northern Europe in the Middle Ages, women enjoyed greater legal and property rights than they do in much of the Muslim world today. And rare was the daughter tortured to death for flirting with a boy.
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Such an attitude implies that only women can and must be interested in laundry and other issued connected with house holding. Such a pupil should also have a genuine interest in people, their behaviour and have empathy for their problems. You and your partner will be at different stages within the cycle of life and she might well prefer to go out more, socialise more and lead a more active life than you. In California for instance, a permit has to be pulled at the local licensing jurisdiction presenting the foundation plans that have been stamped by an engineer. These people support the doctors, clinics, hospitals in conducting day to day operations successfully and help doctors concentration on their core activity that is treating patients. Your lecturer may expect you to provide a critical analysis on a book, journal article, or psychological theory. So, one has to be very careful regarding the credit card payments as the failure rate is high. I have not personally used any of Susana’s products so I can’t comment specifically on the quality although the word on the street is that they are pretty darn good.