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I had a basic knowledge of pipe flow because I had been a process engineer, so why not apply these principles to the human body? Asiruwa thought. When he arrived at SDSU in fall 2015, his first stop was Gents office. I want to learn, Asiruwa recalled telling Gent. I want to be able to think outside the box, to be involved in something that can make life better for others. Learning the Ropes Asiruwa began by taking a new special topics course, Engineering Mechanics in Biomedical Applications in fall 2015, which Gent developed as an extension of his biomedical research and as part of the biomedical engineering minor. I was scared, Asiruwa admitted. It was my first graduate class in a different country, but it was new to everyone. When Gent talked about his research with Sanford Health modeling blood flow through stents, Asiruwa was hooked. Gent described aneurysms and how stent grafts could improve outcomes for patients, he recalled. I knew a brain aneurysm rupture was the cause of my fathers stroke in 2012. Gent has been collaborating with Sanford Health vascular surgeon Dr. Pat Kelly and biomedical engineer Tyler Remund, who is part of Kellys product development team, to evaluate blood flow through stent grafts since 2014. The results of Home Page their work have been published in the Journal of Vascular Surgery.
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But, on her return to the UK in 2015, Matthews had found a surgical team in Denmark willing to work with the frozen tissue and transplant it back into her body in August 2015. Its a very straightforward procedure, Matthews said, adding her main limitations had been finding teams willing to handle the frozen ovarian tissue after it had been in storage for so long. As a result, the technique is a very experimental procedure, she said. Transplanting the ovaries, bit by bit Matthews explained the transplant itself involved reinserting fragments of al Matrooshis ovary bit by bit and, then, waiting for blood vessels to form and infuse into it to make it functional. Because the tissue belonged to the patient, there was no concern about the tissue being rejected and attacked by her immune system. After three months, Matthews harvested three eggs produced by the patients now-functional ovaries and, after waiting a few more months to see whether conception could occur naturally, began IVF treatment. Al Matrooshi became pregnant in April. This is moving from an experimental technique to a practical application, Matthews said. She now wants more facilities to be able to store tissues in this manner and for funding to be made more widely available to cover the procedure for families whose children are diagnosed with conditions like beta thalassaemia or cancer at a young age. Though the survival rates for children with cancer are improving, reaching as high as 90 percent in the UK, according to Matthews, many will have to sacrifice their future fertility. Its a trade-off.
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